Centro Andaluz de Biología Molecular y Medicina Regenerativa

Publications

/Publications
Selected publications in 2018:

  1. Ariza L, Cañete A, Rojas A, Muñoz-Chápuli R, Carmona R. 2018. Role of the Wilms' tumor suppressor gene Wt1 in pancreatic development. Dev Dyn. 247(7):924-933.

  2. Bakula D, Aliper AM, Mamoshina P, Petr MA, Teklu A, Baur JA, Campisi J, Ewald CY, Georgievskaya A, Gladyshev VN, Kovalchuk O, Lamming DW, Luijsterburg MS, Martín-Montalvo A, Maudsley S, Mkrtchyan GV, Moskalev A, Olshansky SJ, Ozerov IV, Pickett A, Ristow M, Zhavoronkov A, Scheibye-Knudsen M. 2018. . Aging (Albany NY). 10(11):3079-3088.

  3. Baranes-Bachar K, Levy-Barda A, Oehler J, Reid DA, Soria-Bretones I, Voss TC, Chung D, Park Y, Liu C, Yoon JB, Li W, Dellaire G, Misteli T, Huertas P, Rothenberg E, Ramadan K, Ziv Y, Shiloh Y. 2018. The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair. Mol Cell. 69(5):866-878.e7.

  4. Barrientos-Moreno M, Murillo-Pineda M, Muñoz-Cabello AM, Prado F. 2018. Histone depletion prevents telomere fusions in pre-senescent cells. PLoS Genet. 14(6):e1007407.

  5. Barroso R, García-Mauriño SM, Tomás-Gallardo L, Andújar E, Pérez-Alegre M, Santero E, Canosa I. 2018. The CbrB Regulon: Promoter dissection reveals novel insights into the CbrAB expression network in Pseudomonas putida. Plos ONE. 13(12):e0209191.

  6. Bhatia V, Valdés-Sánchez L, Rodriguez-Martinez D, Bhattacharya SS. 2018. Formation of 53BP1 foci and ATM activation under oxidative stress is facilitated by RNA:DNA hybrids and loss of ATM-53BP1 expression promotes photoreceptor cell survival in mice. F1000Research. 7:1233.

  7. Calado SM, Garcia-Delgado AB, De la Cerda B, Ponte-Zuñiga B, Bhattacharya SS, Díaz-Corrales FJ. 2018. . Stem Cells Research. 33:251-254.

  8. Cano-González A, Mauro-Lizcano M, Iglesias-Serret D, Gil J, López-Rivas A. 2018. Involvement of both caspase-8 and Noxa-activated pathways in endoplasmic reticulum stress-induced apoptosis in triple-negative breast tumor cells. Cell Death Dis. 9(2):134 .

  9. Capilla-González V, López-Beas J, Escacena N, Aguilera Y, de la Cuesta A, Ruiz-Salmerón R, Martín F, Hmadcha A, Soria B. 2018. PDGF Restores the Defective Phenotype of Adipose-Derived Mesenchymal Stromal Cells from Diabetic Patients. Mol Ther. 26(11):2696-2709.

  10. Carmona-Gutierrez D, Bauer MA, Zimmermann A, Aguilera A et all. 2018. . Microb Cell. 5(1):4-31.

  11. Cobo-Vuilleumier N, Lorenzo PI, Rodríguez NG, Herrera Gómez IG, Fuente-Martin E, López-Noriega L, Mellado-Gil JM, Romero-Zerbo SY, Baquié M, Lachaud CC, Stifter K, Perdomo G, Bugliani M, De Tata V, Bosco D, Parnaud G, Pozo D, Hmadcha A, Florido JP, Toscano MG, de Haan P, Schoonjans K, Sánchez Palazón L, Marchetti P, Schirmbeck R, Martín-Montalvo A, Meda P, Soria B, Bermúdez-Silva FJ, St-Onge L, Gauthier BR. 2018. LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus. Nat Commun. 9(1):1488 .

  12. Cubiles MD, Barroso S, Vaquero-Sedas MI, Enguix A, Aguilera A, Vega-Palas MA. 2018. Epigenetic features of human telomeres. Nucleic Acids Research. 46(5):2347-2355.

  13. De Cárcer G, Huertas P, López-Contreras JA. 2018. . DNA Repair (Amst). 66-67:72-75.

  14. Díaz D, Piquer-Gil M, Recio JS, Martínez-Losa MM, Alonso JR, Weruaga E, Álvarez-Dolado M. 2018. Bone marrow transplantation improves motor activity in a mouse model of ataxia. J Tissue Eng Regen Med. 12(4):e1950-e1961.

  15. Domínguez-Rodríguez A, Mayoral-Gonzalez I, Avila-Medina J, de Rojas-de Pedro ES, Calderón-Sánchez E, Díaz I, Hmadcha A, Castellano A, Rosado JA, Benitah JP, Gomez AM, Ordoñez A, Smani T. 2018. Urocortin-2 Prevents Dysregulation of Ca2+ Homeostasis and Improves Early Cardiac Remodeling After Ischemia and Reperfusion. Front Physiol. 9:813.

  16. Duch A, Canal B, Barroso SI, García-Rubio M, Seisenbacher G, Aguilera A, de Nadal E, Posas F. 2018. Multiple signaling kinases target Mrc1 to prevent genomic instability triggered by transcription-replication conflicts. Nat Commun. 9(1):379 .

  17. Elena-Real CA, Díaz-Quintana A, González-Arzola K, Velázquez-Campoy A, Orzáez M, López-Rivas A, Gil-Caballero S, De la Rosa MÁ, Díaz-Moreno I. 2018. Cytochrome c speeds up caspase cascade activation by blocking 14-3-3?-dependent Apaf-1 inhibition. Cell Death Dis. 9(3):365.

  18. Fernández O, Izquierdo G, Fernández V, Leyva L, Reyes V, Guerrero M, León A, Arnaiz C, Navarro G, Páramo MD, Cuesta A, Soria B, Hmadcha A, Pozo D, Fernandez-Montesinos R, Leal M, Ochotorena I, Gálvez P, Geniz MA, Barón FJ, Mata R, Medina C, Caparrós-Escudero C, Cardesa A, Cuende N; Research Group Study EudraCT 2008-004015-35. 2018. Adipose-derived mesenchymal stem cells (AdMSC) for the treatment of secondary-progressive multiple sclerosis: A triple blinded, placebo controlled, randomized phase I/II safety and feasibility study. PLoS One. 13(5):e0195891.

  19. Flores-Martínez A, García-Núñez A, Rojas A, Cano DA. 2018. . Sci Rep. 8(1):13713 .

  20. Fueyo R, Iacobucci S, Pappa S, Estarás C, Lois S, Vicioso-Mantis M, Navarro C, Cruz-Molina S, Reyes JC, Rada-Iglesias Á, de la Cruz X, Martínez-Balbás MA. 2018. Lineage specific transcription factors and epigenetic regulators mediate TGF?-dependent enhancer activation. Nucleic Acids Res. 46(7):3351-3365.

  21. Gaillard H, García-Benítez F, Aguilera A. 2018. Gene gating at nuclear pores prevents the formation of R loops. Mol Cell Oncol. 5(1):e1405140 .

  22. Garcia-Delgado AB, Valdés-Sánchez L, Calado SM, Diaz-Corrales FJ, Bhattacharya SS. 2018. Rasagiline delays retinal degeneration in a mouse model of retinitis pigmentosa via modulation of Bax/Bcl-2 expression. CNS Neurosci Ther. 24: 448-455 .

  23. García-Rubio M, Aguilera P, Lafuente-Barquero J, Ruiz JF, Simon MN, Geli V, Rondón AG, Aguilera A. 2018. Yra1-bound RNA-DNA hybrids cause orientation-independent transcription-replication collisions and telomere instability. Genes Dev. 32(13-14):965-977.

  24. Gavilan MP, Gandolfo P, Balestra FR, Arias F, Bornens M, Rios RM. 2018. The dual role of the centrosome in organizing the microtubule network in interphase. Embo reports. 19(11). pii: e45942.  .

  25. Gavish-Izakson M, Velpula BB, Elkon R, Prados-Carvajal R, Barnabas GD, Ugalde AP, Agami R, Geiger T, Huertas P, Ziv Y, Shiloh Y. 2018. Nuclear poly(A)-binding protein 1 is an ATM target and essential for DNA double-strand break repair. Nucleic Acids Res. 46(2):730-747.

  26. Guerrero-Martínez JA, Reyes JC. 2018. High expression of SMARCA4 or SMARCA2 is frequently associated with an opposite prognosis in cancer. Sci Rep. 8(1):2043.

  27. Hernández G, Ramírez MJ, Minguillón J, Quiles P, Ruiz de Garibay G, Aza-Carmona M, Bogliolo M, Pujol R, Prados-Carvajal R, Fernández J, García N, López A, Gutiérrez-Enríquez S, Diez O, Benítez J, Salinas M, Teulé A, Brunet J, Radice P, Peterlongo P, Schindler D, Huertas P, Puente XS, Lázaro C, Pujana MÀ, Surrallés J. 2018. Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1. Nat Commun. 9(1):967.

  28. Jimeno S, Camarillo R, Mejías-Navarro F, Fernández-Ávila MJ, Soria-Bretones I, Prados-Carvajal R, Huertas P. 2018. The Helicase PIF1 Facilitates Resection over Sequences Prone to Forming G4 Structures. Cell Rep. 24(12):3262-3273.e4. .

  29. López S, García-Serrano S, Gutierrez-Repiso C, Rodríguez-Pacheco F, Ho-Plagaro A, Santiago-Fernandez C, Alba G, Cejudo-Guillen M, Rodríguez-Cañete A, Valdes S, Garrido-Sanchez L, Pozo D, García-Fuentes E. 2018. Tissue-Specific Phenotype and Activation of iNKT Cells in Morbidly Obese Subjects: Interaction with Adipocytes and Effect of Bariatric Surgery. Obes Surg. 28(9):2774-2782.

  30. López-Beas J, Capilla-González V, Aguilera Y, Mellado N, Lachaud CC, Martín F, Smani T, Soria B, Hmadcha A. 2018. . Mol Ther Nucleic Acids. 2:463-477.

  31. López-López M, López-Cornejo P, Martín VI, Ostos FJ, Checa-Rodríguez C, Prados-Carvajal R, Lebrón JA, Huertas P, Moyá ML. 2018. Importance of hydrophobic interactions in the single-chained cationic surfactant-DNA complexation. J Colloid Interface Sci. 521:197-205.

  32. Lorenzo PI, Cobo-Vuilleumier N, Gauthier BR. 2018. . Curr Opin Pharmacol. 43:1-10.

  33. Luna-Peláez N, García-Domínguez M. 2018. Lyar-mediated recruitment of Brd2 to the chromatin attenuates Nanog downregulation following induction of differentiation. J Mol Biol. 430(8):1084-1097 .

  34. Luque-Sierra A, Alvarez-Amor L, Kleemann R, Martín F, Varela LM. 2018. Extra-Virgin Olive Oil With Natural Phenolic Content Exerts an Anti-Inflammatory Effect in Adipose Tissue and Attenuates the Severity of Atherosclerotic Lesions in Ldlr-/-Leiden Mice. Mol Nutr Food Res. 62(13):e1800295.

  35. Martinez-Losa M, Tracy TE, Ma K, Verret L, Clemente-Perez A, Khan AS, Cobos I, Ho K, Gan L, Mucke L, Alvarez-Dolado M, Palop JJ. 2018. Nav11-Overexpressing Interneuron Transplants Restore Brain Rhythms and Cognition in a Mouse Model of Alzheimer's Disease. Neuron. 98(1):75-89.e5. .

  36. Martínez-Muñoz L, Rodríguez-Frade JM, Barroso R, Sorzano CÓS, Torreño-Pina JA, Santiago CA, Manzo C, Lucas P, García-Cuesta EM, Gutierrez E, Barrio L, Vargas J, Cascio G, Carrasco YR, Sánchez-Madrid F, García-Parajo MF, Mellado M. 2018. . Mol Cell. 70(1):106-119.e10 .

  37. Martínez-Muñoz L, Villares R, Rodríguez-Fernández JL, Rodríguez-Frade JM, Mellado M. 2018. Remodeling our concept of chemokine receptor function: From monomers to oligomers. J Leukoc Biol. 104(2):323-331.

  38. Mauro-Lizcano M, López-Rivas A. 2018. Glutamine metabolism regulates FLIP expression and sensitivity to TRAIL in triple-negative breast cancer cells. Cell Death Dis. 9(2):205.

  39. Mellado-Gil Jose M , Fuente-Martín Esther ,Lorenzo Petra I , Cobo-Vuilleumier Nadia , López-Noriega Livia , Martín-Montalvo Alejandro, de Gracia Herrera Gómez Irene , Ceballos-Chávez Maria,Gómez-Jaramillo Laura , Campos-Caro Antonio, Romero-Zerbo Silvana Y , Rodríguez-Comas Júlia , Servitja Joan-Marc,Rojo-Martinez G ,Hmadcha K , Soria B , Bugliani M , Marchetti P ,Bérmudez-Silva FJ , Reyes JC , Aguilar-Diosdado M and Gauthier B. 2018. The type 2 diabetes-associated HMG20A gene is mandatory for islet beta cell functional maturity. Cell Death & Disease. 9(279).

  40. Moreno-Marín N, Merino JM, Alvarez-Barrientos A, Patel DP, Takahashi S, González-Sancho JM, Gandolfo P, Rios RM, Muñoz A, Gonzalez FJ, Fernández-Salguero PM. 2018. Aryl Hydrocarbon Receptor Promotes Liver Polyploidization and Inhibits PI3K, ERK, and Wnt/?-Catenin Signaling. iScience. 4:44-63 .

  41. Muñoz MF, Argüelles S, Guzman-Chozas M, Guillén-Sanz R, Franco JM, Pintor-Toro JA, Cano M, Ayala A. 2018. Cell tracking, survival, and differentiation capacity of adipose-derived stem cells after engraftment in rat tissue. J Cell Physiol. 233(10):6317-6328.

  42. Muñoz-Pinedo C, López-Rivas A. 2018. A role for caspase-8 and TRAIL-R2/DR5 in ER-stress-induced apoptosis. Cell Death Differ. 25(1):226.

  43. Prado F. 2018. Homologous Recombination: To Fork and Beyond. Genes (Basel). 9(12). pii: E603.

  44. Prados-Carvajal R, López-Saavedra A, Cepeda-García C, Jimeno S, Huertas P. 2018. Multiple roles of the splicing complex SF3B in DNA end resection and homologous recombination. DNA Repair (Amst). 66-67:11-23.

  45. Rose AM, Krishan A, Chakarova CF, Moya L, Chambers S, Hollands M, Illingworth JC, Williams SMG, James HE, Shah AZ, Palmer CNA, Chakravarti A, Berg JN, Batra J, Bhattacharya SS. 2018. MSR1 repeats modulate gene expression and affect risk of breast and prostate cancer. Ann Oncol. 29(5):1292-1303.

  46. Sara González-Arranz, Santiago Cavero, Macarena Morillo-Huesca, Eloísa Andújar, Mónica Pérez-Alegre, Félix Prado, and Pedro San-Segundo. 2018. . Genetics. 209: 997-1015 .

  47. Silva S, Camino LP, Aguilera A. 2018. Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability. PNAS. 115(43):11024-11029 .

  48. Villadiego J, Labrador-Garrido A, Franco JM, Leal-Lasarte M, De Genst EJ, Dobson CM, Pozo D, Toledo-Aral JJ, Roodveldt CR. 2018. Immunization with alpha-synuclein/Grp94 reshapes peripheral immunity and suppresses microgliosis in a chronic parkinsonism model. Glia. 72(7):624-4.

  49. Villamayor L, Rodríguez-Seguel E, Araujo R, Carrasco M, Bru-Tarí E, Mellado-Gil JM, Gauthier BR, Martinelli P, Quesada I, Soria B, Martín F, Cano DA, Rojas A. 2018. GATA6 Controls Insulin Biosynthesis and Secretion in Adult ß cell. Diabetes. 67:448-460.