Centro Andaluz de Biología Molecular y Medicina Regenerativa

Publications

/Publications
Selected publications in 2017:

  1. Aguilera A, Gómez-González B. 2017. DNA-RNA hybrids: the risks of DNA breakage during transcription. Nat Struct Mol Biol. 24(5):439-443.

  2. Bayona-Feliu A, Casas-Lamesa A, Reina O, Bernués J, Azorín F. 2017. Linker histone H1 prevents R-loop accumulation and genome instability in heterochromatin. Nat Commun. 8(1):283.

  3. Bhatia V, Herrera-Moyano E, Aguilera A, and Gómez-González B. 2017. The role of replication-associated repair factors on R-loops. Genes. 8(7).

  4. Caballano-Infantes E, Terron-Bautista J, Beltrán-Povea A, Cahuana GM, Soria B, Nabil H, Bedoya FJ, Tejedo JR. 2017. Regulation of mitochondrial function and endoplasmic reticulum stress by nitric oxide in pluripotent stem cells. World J Stem Cells. 9(2):26-36.

  5. Caballero-Hernandez D, Cejudo-Guillen M, Polo-Padillo J, Fernandez-Montesinos R, Cobo M, Martín F, Franco JM, Roodveldt C, Pozo D. 2017. . Sci Rep. .

  6. Camprubí Camprubí M, Balada Caballé R, Ortega Cano JA, Ortega de la Torre ML, Duran Fernández-Feijoo C, Girabent-Farrés M, Figueras-Aloy J, Krauel X, Alcántara S. 2017. Learning and memory disabilities in IUGR babies: Functional and molecular analysis in a rat model. Brain Behav. 7(3):e00631. .

  7. Cañete A, Carmona R, Ariza L, Sánchez MJ, Rojas A, Muñoz-Chápuli R. 2017. A population of hematopoietic stem cells derives from GATA4-expressing progenitors located in the placenta and lateral mesoderm of mice. Haematologica. 102(4):647-655.

  8. Colijn JM et al. 2017. Prevalence of Age-Related Macular Degeneration in Europe: The Past and the Future. Ophthalmology. (16) 32475-7.

  9. de Los Santos-Velázquez AI, de Oya IG, Manzano-López J, Monje-Casas F. 2017. Late rDNA Condensation Ensures Timely Cdc14 Release and Coordination of Mitotic Exit Signaling with Nucleolar Segregation. Curr Biol. pii: S0960-9822(17)31193-4.

  10. Delgado-Bellido D, Serrano-Saenz S, Fernández-Cortés M, Oliver FJ. 2017. Vasculogenic mimicry signaling revisited: focus on non-vascular VE-cadherin. Mol Cancer. 16(1):65.

  11. Díaz I, Calderón-Sánchez E, Toro RD, Ávila-Médina J, de Rojas-de Pedro ES, Domínguez-Rodríguez A, Rosado JA, Hmadcha A, Ordóñez A, Smani T. 2017. miR-125a, miR-139 and miR-324 contribute to Urocortin protection against myocardial ischemia-reperfusion injury. Sci Rep. 7(1):8898. doi: 10.1038/s41598-017-09198-x.

  12. Feng W, Kawauchi D, Körkel-Qu H, Deng H, Serger E, Sieber L, Lieberman JA, Jimeno-González S, Lambo S, Hanna BS, Harim Y, Jansen M, Neuerburg A, Friesen O, Zuckermann M, Rajendran V, Gronych J, Ayrault O, Korshunov A, Jones DT, Kool M, Northcott PA, Lichter P, Cortés-Ledesma F, Pfister S, Liu HK. 2017. Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme. Nat Commun. 8:14758.

  13. Fernández-García E, Pérez-Gálvez A. 2017. Carotenoid:beta-cyclodextrin stability is independent of pigment structure. Food Chem. 221:1317-1321. .

  14. Garcia-Benítez F, Gaillard H, Aguilera A. 2017. Physical proximity of chromatin to nuclear pores prevents harmful R loop accumulation contributing to maintain genome stability. PNAS. doi: 10.1073/pnas.1707845114.

  15. García-Pichardo D, Cañas JC, García-Rubio ML, Gómez-González B, Rondón AG, Aguilera A. 2017. Histone Mutants Separate R Loop Formation from Genome Instability Induction. Moll Cell. 66(5) P597-609.

  16. Gómez-Cabello D, Checa-Rodríguez C, Abad M, Serrano M, Huertas P. 2017. CtIP-Specific Roles during Cell Reprogramming Have Long-Term Consequences in the Survival and Fitness of Induced Pluripotent Stem Cells. Stem Cell Reports. 432-445.

  17. Gómez-Herreros F, Zagnoli-Vieira G, Ntai I, Martínez-Macías MI, Anderson RM, Herrero-Ruíz A, Caldecott K. 2017. TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription. Nat Commun. 8(1):233. .

  18. Guijo M, Ceballos-Chávez M, Gómez-Marín E, Basurto-Cayuela L, Reyes JC. 2017. Expression of TDRD9 in a subset of lung carcinomas by CpG island hypomethylation protects from DNA damage. Oncotarget. 9(11):9618-9631.

  19. Guintini L, Tremblay M, Toussaint M, D'Amours A, Wellinger RE, Wellinger RJ, Conconi A. 2017. Repair of UV-induced DNA lesions in natural Saccharomyces cerevisiae telomeres is moderated by Sir2 and Sir3, and inhibited by yKu-Sir4 interaction. Nucleic Acids Res. 45(8):4577-4589.

  20. Jimenez-Pacheco A, Franco JM, Lopez S, Gomez-Zumaquero JM, Magdalena Leal-Lasarte M, Caballero-Hernandez DE, Cejudo-Guillén M, Pozo D. 2017. Epigenetic Mechanisms of Gene Regulation in Amyotrophic Lateral Sclerosis. Adv Exp Med Biol. 978:255-275.

  21. Jimeno S, Herrera-Moyano E, Ortega P, Aguilera A. 2017. Differential effect of the overexpression of Rad2/XPG family endonucleases on genome integrity in yeast and human cells. DNA Repair (Amst). 57:66-75 .

  22. Johnson IP, Roodveldt C. 2017. Immunochemical Markers of the Amyloid Cascade in the Hippocampus in Motor Neuron Diseases. Front Neurol. 8; 105 .

  23. Jurado-Ruiz E, Varela LM, Luque A, Berná G, Cahuana G, Martinez-Force E, Gallego-Durán R, Soria B, de Roos B, Romero Gómez M, Martín F. 2017. An extra virgin olive oil rich diet intervention ameliorates the nonalcoholic steatohepatitis induced by a high-fat "Western-type" diet in mice. Mol Nutr Food Res. 61(3).

  24. Ladrón de Guevara-Miranda D, Millón C, Rosell-Valle C, Pérez-Fernández M, Missiroli M, Serrano A, Pavón FJ, Rodríguez de Fonseca F, Martínez-Losa M, Álvarez-Dolado M, Santín LJ, Castilla-Ortega E. 2017. Long-lasting memory deficits in mice withdrawn from cocaine are concomitant with neuroadaptations in hippocampal basal activity, GABAergic interneurons and adult neurogenesis. Dis Model & Mech. 10(3):323-336.

  25. Lafuente-Barquero J, Luke-Glaser S, Graf M, Silva S, Gómez-González B, Lockhart A, Lisby M, Aguilera A, Luke B. 2017. The Smc5/6 complex regulates the yeast Mph1 helicase at RNA-DNA hybrid-mediated DNA damage. PLoS Genet. 13(12):e1007136.

  26. Leal-Lasarte MM, Franco JM, Labrador-Garrido A, Pozo D, Roodveldt C. 2017. Extracellular TDP-43 aggregates target MAPK/MAK/MRK overlapping kinase (MOK) and trigger caspase-3/IL-18 signaling in microglia. FASEB J. (7):2797-2816.

  27. López-Noriega L, Cobo-Vuilleumier N, Narbona-Pérez ÁJ, Araujo-Garrido JL, Lorenzo PI, Mellado-Gil JM, Moreno JC, Gauthier BR, Martín-Montalvo A. 2017. Levothyroxine enhances glucose clearance and blunts the onset of experimental type 1 diabetes mellitus in mice. Br J Pharmacol. doi: 10.1111/bph.13975.

  28. Lorenzo PI, Juárez-Vicente F, Cobo-Vuilleumier N, García-Domínguez M, Gauthier BR. 2017. The Diabetes-Linked Transcription Factor PAX4: From Gene to Functional Consequences. Genes. e101 .

  29. Lukovic D, Diez Lloret A, Stojkovic P, Rodríguez-Martínez D, Perez Arago MA, Rodriguez-Jimenez FJ, González-Rodríguez P, López-Barneo J, Sykova E, Jendelova P, Kostic J, Moreno-Manzano V, Stojkovic M, Bhattacharya SS, Erceg S. 2017. Highly Efficient Neural Conversion of Human Pluripotent Stem Cells in Adherent and Animal-Free Conditions. Stem Cells Transl Med. 6(4):1217-1226.

  30. Martin-Montalvo A, Lorenzo PI, López-Noriega L, Gauthier BR. 2017. Targeting pancreatic expressed PAX genes for the treatment of diabetes mellitus and pancreatic neuroendocrine tumors. Expert Opin Ther Targets. 21(1):77-89.

  31. Martín-Pérez R, Yerbes R, Mora-Molina R, Cano-González A, Arribas J, Mazzone M, López-Rivas A, Palacios C. 2017. Oncogenic p95HER2/611CTF primes human breast epithelial cells for metabolic stress-induced down-regulation of FLIP and activation of TRAIL-R/Caspase-8-dependent apoptosis. Oncotarget. 8(55):93688-93703.

  32. Mendivil-Perez M, Soto-Mercado V, Guerra-Librero A, Fernandez-Gil BI, Florido J, Shen YQ, Tejada MA, Capilla-Gonzalez V, Rusanova I, Garcia-Verdugo JM, Acuña-Castroviejo D, López LC, Velez-Pardo C, Jimenez-Del-Rio M, Ferrer JM, Escames G. 2017. Melatonin enhances neural stem cell differentiation and engraftment by increasing mitochondrial function. J Pineal Res. 63(2).

  33. Mladenova K, Petrova SD, Andreeva TD, Moskova-Doumanova V, Topouzova-Hristova T, Kalvachev Y, Balashev K, Bhattacharya SS, Chakarova C, Lalchev Z, Doumanov JA. 2017. Effects of Ca2+ ions on bestrophin-1 surface films. Colloids Surf B Biointerfaces. 149:226-232.

  34. Muñoz-Galván S, García-Rubio M, Ortega P, Ruiz JF, Jimeno S, Pardo B, Gómez-González B, Aguilera A. 2017. A new role for Rrm3 in repair of replication-born DNA breakage by sister chromatid recombination. PLoS Genet. 13(5):e100678.

  35. Muñoz-Pinedo C, López-Rivas A. 2017. A role for caspase-8 and TRAIL-R2/DR5 in ER-stress-induced apoptosis. Cell Death Differ. .

  36. Ortega Á, Berná G, Rojas A, Martín F, Soria B. 2017. Gene-Diet Interactions in Type 2 Diabetes: The Chicken and Egg Debate. Int J Mol Sci. 18(6). pii: E1188. doi: 10.3390/ijms18061188.

  37. Pertusa JAG, León-Quinto T, Berná G, Tejedo JR, Hmadcha A, Bedoya FJ, Martín F, Soria B. 2017. Zn2+ chelation by serum albumin improves hexameric Zn2+-insulin dissociation into monomers after exocytosis. PLoS One. 12(11):e0187547. .

  38. Prado F, Jimeno-Gonzalez S, Reyes JC. 2017. Histone availability as a strategy to control gene expression. RNA Biology. 14(3):281-286.

  39. Prado F, Mayas D. 2017. Regulation of Replication Fork Advance and Stability by Nucleosome Assembly. Genes (Basel). 8(2). pii: E49.

  40. Rabinowicz N, Mangala LS, Brown KR, Checa-Rodriguez C, Castiel A, Moskovich O, Zarfati G, Trakhtenbrot L, Levy-Barda A, Jiang D, Rodriguez-Aguayo C, Pradeep S, van Praag Y, Lopez-Berestein G, David A, Novikov I, Huertas P, Rottapel R, Sood AK, Izraeli S. 2017. Targeting the centriolar replication factor STIL synergizes with DNA damaging agents for treatment of ovarian cancer. Oncotarget. 8(16):27380-27392.

  41. Ravoityte B, Wellinger RE. 2017. Non-Canonical Replication Initiation: You're Fired!. Genes (Basel). 8(2). pii: E54. REVIEW.

  42. Rodríguez-Martínez D, Martínez-Losa MM, Alvarez-Dolado M. 2017. Cryopreservation of GABAergic Neuronal Precursors for Cell-Based Therapy. PLoS One. 12(1):e0170776.

  43. Rodríguez-Mateo C, Torres B, Gutiérrez G, Pintor-Toro JA. 2017. Downregulation of Lnc-Spry1 mediates TGF-beta-induced epithelial-mesenchymal transition by transcriptional and posttranscriptional regulatory mechanisms. Cell Death Differ. 24(5):785-797.

  44. Romero-Zerbo SY, Ruz-Maldonado I, Espinosa-Jiménez V, Rafacho A, Gómez-Conde AI, Sánchez-Salido L, Cobo-Vuilleumier N, Gauthier BR, Tinahones FJ, Persaud SJ, Bermúdez-Silva FJ. 2017. The cannabinoid ligand LH-21 reduces anxiety and improves glucose handling in diet-induced obese pre-diabetic mice. Sci Rep. 7(1):3946..

  45. Salas-Armenteros I, Pérez-Calero C, Bayona-Feliu A, Tumini E, Luna R, Aguilera A. 2017. Human THO-Sin3A interaction reveals new mechanisms to prevent R-loops that cause genome instability. EMBO J. 36(23):3532-3547.

  46. Sastre-Moreno G, Pryor JM, Díaz-Talavera A, Ruiz JF, Ramsden DA, Blanco L. 2017. Polu tumor variants decrease the efficiency and accuracy of NHEJ. Nucleic Acids Res. 45(17):10018-10031. .

  47. Sastre-Moreno G, Pryor JM, Moreno-Oñate M, Herrero-Ruiz AM, Cortés-Ledesma F, Blanco L, Ramsden DA, Ruiz JF. 2017. Regulation of human pol-lambda by ATM-mediated phosphorylation during non-homologous end joining. DNA Repair (Amst). 51:31-45.

  48. Schellenberg MJ, Lieberman JA, Herrero-Ruiz A, Butler LR, Williams JG, Muñoz-Cabello AM, Mueller GA, London RE, Cortés-Ledesma F, Williams RS. 2017. ZATT (ZNF451)-mediated resolution of topoisomerase 2 DNA-protein cross-links. Science. doi:10.1126/science.aam6468 .

  49. Smani T, Gallardo-Castillo I, Ávila-Médina J, Jimenez-Navarro MF, Ordoñez A, Hmadcha A. 2017. Impact of diabetes on cardiac and vascular disease: Role of calcium signaling. Curr Med Chem. 63(2).

  50. Soler-Oliva ME, Guerrero-Martínez JA, Bachetti V, Reyes JC. 2017. Analysis of the relationship between co-expression domains and chromatin 3D organization. PLoS Comput Biol. 13(9):e1005708.

  51. Soria-Bretones I, Cepeda-García C, Checa-Rodriguez C, Heyer V, Reina-San-Martin B, Soutoglou E, Huertas P. 2017. DNA end resection requires constitutive sumoylation of CtIP by CBX4. Nat Commun. 8(1):113.

  52. Sot B, Rubio-Muñoz A, Leal-Quintero A, Martínez-Sabando J, Marcilla M, Roodveldt C, Valpuesta, JM. 2017. The chaperonin CCT inhibits assembly of alpha-synuclein amyloid fibrils by a specific, conformation-dependent interaction. Sci Rep. 7:40859.

  53. Toscano MG, van der Velden J, van der Werf S, Odijk M, Roque A, Camacho-Garcia RJ, Herrera-Gomez IG, Mancini I, de Haan P. 2017. Generation of a Vero-Based Packaging Cell Line to Produce SV40 Gene Delivery Vectors for Use in Clinical Gene Therapy Studies. Mol Ther Methods Clin Dev. 6:124-134. .