Centro Andaluz de Biología Molecular y Medicina Regenerativa

Publications

/Publications
Selected publications in 2024:

  1. Basurto-Cayuela L, Guerrero-Martínez JA, Gómez-Marín E, Sánchez-Escabias E, Escaño-Maestre M, Ceballos-Chávez M, Reyes JC. 2024. SWI/SNF-dependent genes are defined by their chromatin landscape. Cell Rep. 43(3):113855.

  2. Bhandari, J, Guillén-Mendoza, C, Banks, K, Eliaz, L, Southwell, S, Eyaa, D, Luna, R, Aguilera, A, & Xue, X. 2024. The molecular chaperone ALYREF promotes R-loop resolution and maintains genome stability. J Biol Chem. 13;300(12):107996.

  3. Bruno F, Coronel-Guisado C and Gonzalez-Aguilera C. 2024. Collisions of RNA polymerases behind the replication fork promote alternative splicing in newly replicated chromatin. Mol Cell. Online ahead of print.

  4. Casimiro-Soriguer, C S, Pérez-Florido, J, Robles, E A, Lara, M, Aguado, A, Rodríguez Iglesias, M A, Lepe, J A, García, F, Pérez-Alegre, M, Andújar, E, Jiménez, V E, Camino, L P, Loruso, N, Ameyugo, U, Vazquez, I M, Lozano, C M, Chaves, J A, & Dopazo, J. 2024. The integrated genomic surveillance system of Andalusia (SIEGA) provides a One Health regional resource connected with the clinic. Scientific Reports. 14(1):19200.

  5. Castejón-Griñán M, Albers E, Simón-Carrasco L, Aguilera P, Sbroggio M, Pladevall-Morera D, Ingham A, Lim E, Guillen-Benitez A, Pietrini E, Lisby M, Hickson ID, Lopez-Contreras AJ. 2024. PICH deficiency limits the progression of MYC-induced B-cell lymphoma. Blood cancer journal. 14(1):16.

  6. Ceppi, I, Dello Stritto, M R, Mütze, M, Braunshier, S, Mengoli, V, Reginato, G, Võ, H M P, Jimeno, S, Acharya, A, Roy, M, Sanchez, A, Halder, S, Howard, S M, Guérois, R, Huertas, P, Noordermeer, S M, Seidel, R, & Cejka, P. 2024. Mechanism of BRCA1-BARD1 function in DNA end resection and DNA protection. Nature. Online ahead of print..

  7. Cobo-Vuilleumier, N, Lorenzo, P I, Martin Vazquez, E, López Noriega, L, Nano, R, Piemonti, L, Martín, F, & Gauthier, B R. 2024. Enhancing human islet xenotransplant survival and function in diabetic immunocompetent mice through LRH-1/NR5A2 pharmacological activation. Front Immunol. 15:1470881.

  8. Coelewij, L, Adriani, M, Dönnes, P, Waddington, K E, Ciurtin, C, Havrdova, E K, ABIRISK Consortium, Farrell, R, Nytrova, P, Pineda-Torra, I, & Jury, E C. 2024. Patients with multiple sclerosis who develop immunogenicity to interferon-beta have distinct transcriptomic and proteomic signatures prior to treatment which are associated with disease severity. CLINICAL IMMUNOLOGY. 267:110339.

  9. Condezo YB, Sainz-Urruela R, Gomez-H L, Salas-Lloret D, Felipe-Medina N, Bradley R, Wolff ID, Tanis S, Barbero JL, Sánchez-Martín M, de Rooij D, Hendriks IA, Nielsen ML, Gonzalez-Prieto R, Cohen PE, Pendas AM, Llano E. 2024. RNF212B E3 ligase is essential for crossover designation and maturation during male and female meiosis in the mouse. PNAS. 121(25):e2320995121.

  10. Davidson, B S A, Arcila-Galvis, J E, Trevisan-Herraz, M, Mikulasova, A, Brackley, C A, Russell, L J, & Rico, D. 2024. Evolutionarily conserved enhancer-associated features within the MYEOV locus suggest a regulatory role for this non-coding DNA region in cancer. Front Cell Dev Biol. 12:1294510.

  11. Duardo RC, Marinello J, Russo M, Morelli S, Pepe S, Guerra F, Gómez-González B, Aguilera A, Capranico G. 2024. Human DNA topoisomerase I poisoning causes R loop-mediated genome instability attenuated by transcription factor IIS. Science advances. 10(21):eadm8196.

  12. Durán-Díaz I, Sarmiento A, Fondón I, Bodineau C, Tomé M, Durán RV. 2024. A Robust Method for the Unsupervised Scoring of Immunohistochemical Staining. Entropy. 26(2):165.

  13. Espadas I, Cáliz-Molina MÁ, López-Fernández-Sobrino R, Panadero-Morón C, Sola-García A, Soriano-Navarro M, Martínez-Force E, Venegas-Calerón M, Salas JJ, Martín F, Gauthier BR, Alfaro-Cervelló C, Martí-Aguado D, Capilla-González V, Martín-Montalvo A. 2024. Hydroxycitrate delays early mortality in mice and promotes muscle regeneration while inducing a rich hepatic energetic status. Aging Cell. Online ahead of print.

  14. Flores, N G, Fernández-Aroca, D M, Garnés-García, C, Domínguez-Calvo, A, Jiménez-Suárez, J, Sabater, S, Fernández-Aroca, P, Andrés, I, Cimas, F J, de Cárcer, G, Belandia, B,. 2024. The CDK12-BRCA1 signaling axis mediates dinaciclib-associated radiosensitivity through p53-mediated cellular senescence. Mol Oncol. Online ahead of print.

  15. Gaillard, H, Ciudad, T, Aguilera, A, & Wellinger, R E. 2024. Histone variant H2AZ is needed for efficient transcription-coupled NER and genome integrity in UV challenged yeast cells. PLoS genetics. 20(9):e1011300..

  16. Gallego-Durán R, Ampuero J, Maya-Miles D, Pastor-Ramírez H, Montero-Vallejo R, Rivera-Esteban J, Álvarez-Amor L, Pareja MJ, Rico MC, Millán R, Robles-Frías MJ, Aller R, Rojas Á, Muñoz-Hernández R, Gil-Gómez A, Gato S, García-Lozano M, Arias-Loste MT, Abad J, Calleja JL, Andrade RJ, Crespo J, González-Rodríguez Á, García-Monzón C, Andreola F, Pericás JM, Jalan R, Martín-Bermudo F, Romero-Gómez M. 2024. Fibroblast growth factor 21 is a hepatokine involved in MASLD progression. United European Gastroenterol J. Online ahead of print..

  17. Gallego-Durán R, Ampuero J, Maya-Miles D, Pastor-Ramírez H, Montero-Vallejo R, Rivera-Esteban J, Álvarez-Amor L, Pareja MJ, Rico MC, Millán R, Robles-Frías MJ, Aller R, Rojas Á, Muñoz-Hernández R, Gil-Gómez A, Gato S, García-Lozano M, Arias-Loste MT, Abad J, Calleja JL, Andrade RJ, Crespo J, González-Rodríguez Á, García-Monzón C, Andreola F, Pericás JM, Jalan R, Martín-Bermudo F, Romero-Gómez M. 2024. Fibroblast growth factor 21 is a hepatokine involved in MASLD progression. United European Gastroenterol J. Online ahead of print..

  18. Gallego-Durán, R, Ampuero, J, Maya-Miles, D, Pastor-Ramírez, H, Montero-Vallejo, R, Rivera-Esteban, J, Álvarez-Amor, L, Pareja, M J, Rico, M C, Millán, R, Robles-Frías, M J, Aller, R, Rojas, Á, Muñoz-Hernández, R, Gil-Gómez, A, Gato, S, García-Lozano, M, Arias-Loste, M T, Abad, J, Calleja, J L, ? Romero-Gómez, M. 2024. Fibroblast growth factor 21 is a hepatokine involved in MASLD progression. United European Gastroenterol J. (8):1056-1068.

  19. García-Rodríguez N, Domínguez-García I, Domínguez-Pérez MDC, Huertas P. 2024. EXO1 and DNA2-mediated ssDNA gap expansion is essential for ATR activation and to maintain viability in BRCA1-deficient cells. Nucleic Acids Res. 52(11):6376-6391.

  20. González-Arzola K. 2024. The nucleolus: Coordinating stress response and genomic stability. BIOCHIMICA ET BIOPHYSICA ACTA. 195029.

  21. Hine C, Ponti AK, Cáliz-Molina MÁ, Martín-Montalvo A. 2024. H2S serves as the immunoregulatory essence of apoptotic cell death. Cell Metab. 36(1):3-5.

  22. Ilié, M, Lake, V, de Alava, E, Bonin, S, Chlebowski, S, Delort, A, Dequeker, E, Al-Dieri, R, Diepstra, A, Carpén, O, Eloy, C, Fassina, A, Fend, F, Fernandez, P L, Gorkiewicz, G, Heeke, S, Henrique, R, Hoefler, G, Huertas, P, Hummel, M, ? Hofman, P. 2024. Standardization through education of molecular pathology: a spotlight on the European Masters in Molecular Pathology. Virchows Arch. Online ahead of print..

  23. James C, Trevisan-Herraz M, Juan D, Rico D. 2024. Evolutionary analysis of gene ages across TADs associates chromatin topology with whole-genome duplications. Cell Rep. 43(4):113895.

  24. Lafuente-Barquero J, Svejstrup JQ, Luna R, Aguilera A. 2024. Expression of human RECQL5 in Saccharomyces cerevisiae causes transcription defects and transcription-associated genome instability. Mol Genet Genomics. 26;299(1):59.

  25. Lara-Ureña, N, Gómez-Marín, E, Pozuelo-Sánchez, I, Reyes, J C, & García-Domínguez, M. 2024. SARS-CoV-2 E protein interacts with BRD2 and BRD4 SEED domains and alters transcription in a different way than BET inhibition. Cell Mol Life Sci. 81(1):313.

  26. Lluch, A, Latorre, J, Oliveras-Cañellas, N, Fernández-Sánchez, A, Moreno-Navarrete, J M, Castells-Nobau, A, Comas, F, Buxò, M, Rodríguez-Hermosa, J I, Ballester, M, Espadas, I, Martin-Montalvo, A, Zhang, B, Zhou, Y, Burkhardt, R, Höring, M, Liebisch, G, Castellanos-Rubio, A, Santin, I, Kar, A, ? Ortega, F J . 2024. A novel long non-coding RNA connects obesity to impaired adipocyte function. Mol Metab. Online ahead of print..

  27. López-Bermudo, L, Moreno-Chamba, B, Salazar-Bermeo, J, Hayward, N J, Morris, A, Duncan, G J, Russell, W R, Cárdenas, A, Ortega, Á, Escudero-López, B, Berná, G, Martí Bruña, N, Duncan, S H, Neacsu, M, & Martin, F. 2024. Persimmon Fiber-Rich Ingredients Promote Anti-Inflammatory Responses and the Growth of Beneficial Anti-Inflammatory Firmicutes Species from the Human Colon. Nutrients. 16(15):2518.

  28. Luna R, Gómez-González B, Aguilera A. 2024. RNA biogenesis and RNA metabolism factors as R-loop suppressors: a hidden role in genome integrity. Genes Dev. 38(11-12):504-527.

  29. Manguso N, Kim M, Joshi N, Al Mahmud MR, Aldaco J, Suzuki R, Cortes-Ledesma F, Cui X, Yamada S, Takeda S, Giuliano A, You S, Tanaka H. 2024. TDP2 is a regulator of estrogen-responsive oncogene expression. NAR Cancer. 6(2):zcae016.

  30. Medrano M, Contreras M, Caballero-Velázquez T, Martínez L, Bejarano-García JA, Calderón-Ruiz R, García-Calderón CB, Rosado IV, Pérez-Simón JA. 2024. Cannabinoids induce cell death in leukaemic cells through Parthanatos and PARP-related metabolic disruptions. Br J Cancer. 130(9):1529-1541.

  31. Mérida-Cerro JA, Maraver-Cárdenas P, Rondón AG, Aguilera A. 2024. Rat1 promotes premature transcription termination at R-loops. Nucleic Acids Res. 52(7):3623-3635.

  32. Miyazaki I, Asanuma M, Díaz-Corrales FJ. 2024. Editorial: Glial crosstalk in neurological disorders. Front Cell Dev Biol. 12:1515052.

  33. Montero-Vallejo R, Maya-Miles D, Ampuero J, Martín F, Romero-Gómez M, Gallego-Durán R. 2024. Novel insights into metabolic-associated steatotic liver disease preclinical models. Liver Int. 44(3):644-662.

  34. Morales-Gallel R, Ulloa-Navas MJ, García-Tárraga P, Prat-Acín R, Reynés G, Pérez-Borredá P, Rubio L, Capilla-González V, Ferrer-Lozano J, García-Verdugo JM. 2024. BCAS1 defines a heterogeneous cell population in diffuse gliomas. Oncotarget. 15:49-64.

  35. Moshtaghion SM, Caballano-Infantes E, Plaza Reyes Á, Valdés-Sánchez L, Fernández PG, de la Cerda B, Riga MS, Álvarez-Dolado M, Peñalver P, Morales JC, Díaz-Corrales FJ. 2024. Piceid Octanoate Protects Retinal Cells against Oxidative Damage by Regulating the Sirtuin 1/Poly-ADP-Ribose Polymerase 1 Axis In Vitro and in rd10 Mice. Antioxidants. 13(2):201.

  36. Muñoz S, Barroso S, Badra-Fajardo N, Marqueta-Gracia JJ, García-Rubio ML, Ubieto-Capella P, Méndez J, Aguilera A. 2024. SIN3A histone deacetylase action counteracts MUS81 to promote stalled fork stability. Cell Rep. 43(2):113778.

  37. Nguyen BA, Singh V, Afrin S, Yakubovska A, Wang L, Ahmed Y, Pedretti R, Fernandez-Ramirez MDC, Singh P, P?ka?a M, Cabrera Hernandez LO, Kumar S, Lemoff A, Gonzalez-Prieto R, Sawaya MR, Eisenberg DS, Benson MD, Saelices L. 2024. Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy. Nat Commun. 15(1):581.

  38. Polo-Generelo S, Rodríguez-Mateo C, Torres B, Pintor-Tortolero J, Guerrero-Martínez JA, König J, Vázquez J, Bonzón-Kulichenco E, Padillo-Ruiz J, de la Portilla F, Reyes JC, Pintor-Toro JA. 2024. Serpine1 mRNA confers mesenchymal characteristics to the cell and promotes CD8+ T cells exclusion from colon adenocarcinomas. Cell Death Discov. 10(1):116.

  39. Riga MS, Pérez-Fernández M, Miquel-Rio L, Paz V, Campa L, Martínez-Losa M, Esteban FJ, Callado LF, Meana J, Artigas F, Bortolozzi A, Álvarez-Dolado M. 2024. Scn1a haploinsufficiency in the prefrontal cortex engages to cognitive impairment and depressive phenotype. Brain. Online ahead of print..

  40. Roodveldt C, Bernardino L, Oztop-Cakmak O, Dragic M, Fladmark KE, Ertan S, Busra A, Pita C, Ciglar L, Garraux G, Williams-Gray C, Pacheco R, Romero-Ramos M. 2024. The immune system in Parkinson's disease: what we know so far. Brain. Online ahead of print.

  41. Roodveldt, C, Bernardino, L, Oztop-Cakmak, O, Dragic, M, Fladmark, K E, Ertan, S, Aktas, B, Pita, C, Ciglar, L, Garraux, G, Williams-Gray, C, Pacheco, R, & Romero-Ramos, M. 2024. The immune system in Parkinson's disease: what we know so far. Brain. 147(10):3306-3324.

  42. Salas-Lloret D, García-Rodríguez N, Soto-Hidalgo E, González-Vinceiro L, Espejo-Serrano C, Giebel L, Mateos-Martín ML, de Ru AH, van Veelen PA, Huertas P, Vertegaal ACO, González-Prieto R. 2024. BRCA1/BARD1 ubiquitinates PCNA in unperturbed conditions to promote continuous DNA synthesis. Nat Commun. 15(1):4292.

  43. Seoane R, Lama-Díaz T, Romero AM, El Motiam A, Martínez-Férriz A, Vidal S, Bouzaher YH, Blanquer M, Tolosa RM, Castillo Mewa J, Rodríguez MS, García-Sastre A, Xirodimas D, Sutherland JD, Barrio R, Alepuz P, Blanco MG, Farràs R, Rivas C. 2024. SUMOylation modulates eIF5A activities in both yeast and pancreatic ductal adenocarcinoma cells. Cell Mol Biol Lett. 29(1):15.

  44. Silva-Hucha S, Fernández de Sevilla ME, Humphreys KM, Benson FE, Franco JM, Pozo D, Pastor AM, Morcuende S. 2024. VEGF expression disparities in brainstem motor neurons of the SOD1G93A ALS model: Correlations with neuronal vulnerability. Neurotherapeutics. 21(3):e00340.

  45. Simón-Carrasco L, Pietrini E, López-Contreras AJ. 2024. Integrated analysis of FHIT gene alterations in cancer. Cell Cycle. (1):92-113.

  46. Valdés-Sánchez, L, Moshtaghion, S M, Caballano-Infantes, E, Peñalver, P, Rodríguez-Ruiz, R, González-Alfonso, J L, Plou, F J, Desmet, T, Morales, J C, & Díaz-Corrales, F J. 2024. Synthesis and Evaluation of Glucosyl-, Acyl- and Silyl- Resveratrol Derivatives as Retinoprotective Agents: Piceid Octanoate Notably Delays Photoreceptor Degeneration in a Retinitis Pigmentosa Mouse Model. Pharmaceuticals (Basel). 17(11):1482.

  47. Yalçin Z, Lam SY, Peuscher MH, van der Torre J, Zhu S, Iyengar PV, Salas-Lloret D, de Krijger I, Moatti N, van der Lugt R, Falcone M, Cerutti A, Bleijerveld OB, Hoekman L, González-Prieto R, Jacobs JJL. 2024. UBE2D3 facilitates NHEJ by orchestrating ATM signalling through multi-level control of RNF168. Nat Commun. 15(1):5032.

  48. Yáñez-Vilches A, Romero AM, Barrientos-Moreno M, Cruz E, González-Prieto R, Sharma S, Vertegaal ACO, Prado F. 2024. Physical interactions between specifically regulated subpopulations of the MCM and RNR complexes prevent genetic instability. PLoS Genet. Online ahead of print..

  49. Zhao, C, Plaza Reyes, A, Schell, J P, Weltner, J, Ortega, N M, Zheng, Y, Björklund, Å K, Baqué-Vidal, L, Sokka, J, Torokovic, R, Cox, B, Rossant, J, Fu, J, Petropoulos, S, & Lanner, F. 2024. A comprehensive human embryo reference tool using single-cell RNA-sequencing data. Nature methods. Online ahead of print.